This talk considers the role twentieth century models of intermediary metabolism played in the constitution of ideas of homeostasis and interiority for organisms vis-à-vis their environments. These are contrasted with contemporary theories of metabolic disorder, explored via ethnographic work observing biomedical research. Homeostasis seemed that it had no end, it was all return. So what can come after it save death? Practically speaking, the topical concerns of biomedicine of beta-cell exhaustion, inflammation, genomic instability, hyperphagia, and dysbiology do. These apparently technical or medical issues will be translated here as cultural theoretical ones of the time after homeostasis.